Despite the increased genomic complexity associated with progression, advanced tumors remain dependent on MYC expression, that drives the progression of monoclonal gammopathy to MM. We observed recurrent copy number alterations, structural variations, chromothripsis, driver mutations, APOBEC mutational activity, and a progressive decrease in immunoglobulin. Nude art 21181 - original figurative sketch (2021) Drawing by Maria Shedrina Original Reproductions Licenses Ink on Paper, 16.5x11.4 in. Siberian Mouse Masha Babko stock photos are available in a variety of sizes and formats to fit your needs. Moreover, we identified frequent insertional mutagenesis by endogenous retro-elements as a murine specific mechanism to activate NF-kB and IL6 signaling pathways shared with human MM. Here, we profile the genomic landscape of 118 genetically engineered VkMYC MM and reveal that it recapitulates the genomic heterogenenity and life history of human MM. Browse Getty Images premium collection of high-quality, authentic Siberian Mouse Masha Babko stock photos, royalty-free images, and pictures. We observed recurrent copy number alterations, structural variations, chromothripsis, driver mutations, APOBEC mutational activity, and a progressive decrease in immunoglobulin transcription that inversely correlates with proliferation. Here, we profile the genomic landscape of 118 genetically engineered Vk*MYC MM and reveal that it recapitulates the genomic heterogenenity and life history of human MM. MM mouse models represent an opportunity to overcome this temporal limitation. Clincal efforts designed to deconvolute such mechanisms are challenged by the long lead time between monoclonal gammopathy and its transformation to MM.
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